isocitrate dehydrogenase - ορισμός. Τι είναι το isocitrate dehydrogenase
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Τι (ποιος) είναι isocitrate dehydrogenase - ορισμός

CLASS OF ENZYMES
Isocitrate dehydrogenase (NADP+); Idh1; EC 1.1.1.42; Isocitrate:NADP+ oxidoreductase (decarboxylating)
  •  s2cid = 36093146 }}</ref>
  •  doi = 10.1128/JB.01799-07 }}</ref>
  • thumb
  • Decarboxylation of oxalosuccinate.<ref name="nfr154197/32"/>
  • Oxidoreductase step where NAD<sup>+</sup> is used to accept a hydride.<ref name="nfr154197/32"/>
  • Saturation of the alpha-beta unsaturated double bond.<ref name="nfr154197/32"/>
  • Porcine Mitochondrial NADP<sup>+</sup>-dependent Isocitrate Dehydrogenase Complexed with Mn<sup>2+</sup> and Isocitrate.<ref name="hl67774"/>
  • Porcine IDH complex, Arg AA stabilizing isocitrate in the active site. residues Arg110, Arg133, and Arg101 are the three main stabilizing amino acids. They help to hold isocitrate in the active site and in the right orientation for isocitrate dehydrogenase to take place.<ref name="hl67774"/>
  • Porcine Enzyme complex; Active site isocitrate and adjacent A.A.<ref name="hl67774"/>
  •  doi-access = free }}</ref>
  • One active site on the Porcine NADP<sup>+</sup> dependent enzyme (green).<ref name="hl67774"/> Porcine enzyme is a homodimer and has another active site on the other side.

IDH2         
MAMMALIAN PROTEIN FOUND IN HOMO SAPIENS
IDH2 (gene); Isocitrate dehydrogenase 2
Isocitrate dehydrogenase [NADP], mitochondrial is an enzyme that in humans is encoded by the IDH2 gene.
Isocitrate dehydrogenase (NAD+)         
Isocitrate dehydrogenase (NAD+) (, isocitric dehydrogenase, beta-ketoglutaric-isocitric carboxylase, isocitric acid dehydrogenase, NAD dependent isocitrate dehydrogenase, NAD isocitrate dehydrogenase, NAD-linked isocitrate dehydrogenase, NAD-specific isocitrate dehydrogenase, NAD isocitric dehydrogenase, isocitrate dehydrogenase (NAD), IDH (ambiguous), nicotinamide adenine dinucleotide isocitrate dehydrogenase) is an enzyme with systematic name isocitrate:NAD+ oxidoreductase (decarboxylating). This enzyme catalyses the following chemical reaction
Isocitrate/isopropylmalate dehydrogenase family         
PROTEIN FAMILY CONSISTING OF THE EVOLUTIONARY RELATED ENZYMES ISOCITRATE DEHYDROGENASE, 3-ISOPROPYLMALATE DEHYDROGENASE AND TARTRATE DEHYDROGENASE
In molecular biology, the isocitrate/isopropylmalate dehydrogenase family is a protein family consisting of the evolutionary related enzymes isocitrate dehydrogenase, 3-isopropylmalate dehydrogenase and tartrate dehydrogenase.

Βικιπαίδεια

Isocitrate dehydrogenase

Isocitrate dehydrogenase (IDH) (EC 1.1.1.42) and (EC 1.1.1.41) is an enzyme that catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate (α-ketoglutarate) and CO2. This is a two-step process, which involves oxidation of isocitrate (a secondary alcohol) to oxalosuccinate (a ketone), followed by the decarboxylation of the carboxyl group beta to the ketone, forming alpha-ketoglutarate. In humans, IDH exists in three isoforms: IDH3 catalyzes the third step of the citric acid cycle while converting NAD+ to NADH in the mitochondria. The isoforms IDH1 and IDH2 catalyze the same reaction outside the context of the citric acid cycle and use NADP+ as a cofactor instead of NAD+. They localize to the cytosol as well as the mitochondrion and peroxisome.